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Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment

Niklas Kehl1, Tim R Wagner1, Simon Steiger2

  • 1German Cancer Research Center (DKFZ), JRG Hematology and Immune Engineering, Heidelberg, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.

Cancer Cell
|August 10, 2026
PubMed
Summary

Tumor-reactive T cells in multiple myeloma (MM) and acute myeloid leukemia (AML) possess a unique effector program. A new classifier, TFiT, identifies these cells and predicts immunotherapy response in bone marrow cancers.

Keywords:
TCR repertoireTFiTacute myeloid leukemiabispecific antibodiesbone marrow microenvironmentimmune biomarkerimmunopeptidomicsmultiple myelomanoncanonical antigenstumor-reactive T cells

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