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The HLA-C*08:01:45 Allele, Identified by Next-Generation Sequencing in an Indian Individual

Samir Agarwal1, Shikha Kumari1, Neha Bairagi1

  • 1Department of Lab Science and Molecular Medicine, Army Hospital Research and Referral, New Delhi, India.

HLA
|August 10, 2026
PubMed

Abstract:

The HLA-C*08:01:45 allele differs from HLA-C*08:01:01:01, by one synonymous substitution, c.111C>A in exon 2.

Keywords:
HLA‐C*08:01:45Indiannext generation sequencingnovel allele

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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