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Updated: Aug 12, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Published on: June 27, 2020

ETS transcription factor ELK3: Molecular insights and translational horizons in cancer (Review)

Zhenzhe Liu1, Zhong Wei2, Zhensheng Li3

  • 1Huankui Academy, Nanchang University, Nanchang, Jiangxi 330031, P.R. China.

Oncology Letters
|August 11, 2026
PubMed

Insights

Transcription factors regulate gene expression and tumor progression. This review explores ELK3's role in tumorigenesis, its diagnostic value as a biomarker, and its potential as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Tumorigenesis involves genetic, immune, and metabolic factors.
  • Transcription factors are crucial regulators of gene expression and cellular processes.
  • Abnormal transcription factor activity is linked to cancer initiation and progression.

Purpose of the Study:

  • To review the structure and regulation of ELK3.
  • To summarize ELK3's functions in various tumors.
  • To explore ELK3's diagnostic and therapeutic potential in cancer.

Main Methods:

  • Literature review of ELK3's role in tumorigenesis.
  • Analysis of ELK3's involvement in signaling pathways.
  • Evaluation of ELK3 as a biomarker and therapeutic target.

Main Results:

  • ELK3, an ETS transcription factor, is implicated in tumor initiation, progression, invasion, and metastasis.
  • ELK3 regulates key cancer-related processes like angiogenesis and epithelial-mesenchymal transition.
  • ELK3 exhibits potential as a diagnostic biomarker and a target for cancer therapy.

Conclusions:

  • ELK3 plays a significant role in multiple aspects of tumor development.
  • Understanding ELK3's function can lead to novel diagnostic and therapeutic strategies.
  • Targeting ELK3 may offer a promising approach for tumor-specific treatment.
Keywords:
ELK3ETS transcription factorbiomarkeroncogenetumor

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