Recent advances in Prussian blue analogue based nanomaterials for sensitive biosensing

Area of Science:

• Materials Science
• Analytical Chemistry
• Nanotechnology

Background:

• Precise biomarker detection is vital for clinical diagnosis, environmental monitoring, and food safety.
• Sensing material properties significantly impact sensor performance.
• Prussian blue analogues (PBAs) are emerging as promising biological sensing materials due to their unique structural and electrochemical properties.

Purpose of the Study:

• To review recent advancements in sensors utilizing Prussian blue analogues (PBAs) for sensing applications.
• To provide a comprehensive overview of PBA-based materials, including their structure, properties, preparation, and modification.
• To highlight the diverse applications of PBAs in various sensor types, such as electrochemical, electrochemiluminescence, chemiluminescence, and colorimetry.

Main Methods:

• Literature review of recent research on PBA-based sensing materials.
• Analysis of structural, chemical, and physiochemical properties of typical PBAs.
• Categorization and discussion of PBA applications in different sensing platforms.

Main Results:

• PBAs exhibit advantageous features like 3D porous structures, tunable enzyme-like catalytic activity, conductivity, and redox reversibility.
• Significant progress has been made in developing PBA-based sensors for various detection tasks.
• PBAs have demonstrated successful applications across electrochemical, electrochemiluminescence, chemiluminescence, and colorimetry sensing modalities.

Conclusions:

• PBA-based materials offer significant potential for developing highly sensitive and precise biosensors.
• Further research into PBA modification is crucial for overcoming current challenges and advancing sensor technology.
• This review provides insights into the current status and future directions for PBA-based sensing materials.