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Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
Predicting the initiation for home oxygen therapy after lung resection using low-attenuation lung volume on computed
Ryo Karita1,2, Kazuhisa Tanaka1,2, Yuki Sata1,2
1Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Journal of Thoracic Disease
|August 12, 2026
Summary
Preoperative low-attenuation lung volume (LAV) on CT scans can predict the need for home oxygen therapy (HOT) after lung resection surgery. This quantitative CT analysis helps identify patients at higher risk for requiring postoperative oxygen support.
Area of Science:
- Pulmonary Medicine
- Radiology
- Thoracic Surgery
Background:
- Home oxygen therapy (HOT) is crucial for managing chronic respiratory diseases and post-lung resection patients.
- Evaluating the risk of needing HOT after surgery is essential for patient care.
- Preoperative assessment aids in planning and managing postoperative respiratory support.
Purpose of the Study:
- To determine if preoperative low-attenuation lung volume (LAV) on computed tomography (CT) can predict the need for HOT after lung resection.
- To identify quantitative CT metrics for predicting postoperative oxygen requirements.
- To improve risk stratification for patients undergoing lung resection.
Main Methods:
- Retrospective review of 259 patients undergoing lobectomy or segmentectomy (Jan 2019-Dec 2020).
- Calculation of preoperative low-attenuation lung volume percentage (LAV%) from thin-slice contrast-enhanced CT images.
- Comparison of clinical factors, including LAV% and %FEV1.0, between patients requiring and not requiring HOT post-surgery.
Main Results:
- 5.4% of patients (14/259) required HOT post-surgery.
- Preoperative LAV% (OR 1.17) and %FEV1.0 (OR 0.96) were independent predictors of HOT initiation.
- A combined model of LAV% and %FEV1.0 showed significant predictive value (AUC 0.822).
Conclusions:
- Preoperative LAV% is a significant, independent predictor for initiating HOT after lung resection.
- Quantitative CT analysis of emphysematous changes can identify high-risk patients for postoperative oxygen support.
- LAV% offers a valuable tool for preoperative risk assessment in thoracic surgery patients.
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