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Evolutionary patterns and research frontiers in ventilator-induced lung injury: a bibliometric analysis (2000-2024)
Yingliang Wu1,2, Linghui Pan1
1Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, China.
Journal of Thoracic Disease
|August 12, 2026
Summary
This bibliometric analysis reveals a significant global increase in research on ventilator-induced lung injury (VILI). Current hotspots focus on molecular mechanisms and precision ventilation, shifting from earlier clinical strategies.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Biomedical Engineering
Background:
- Ventilator-induced lung injury (VILI) is a critical complication of mechanical ventilation, significantly impacting patient morbidity and mortality.
- Despite extensive research, the global landscape, collaborations, and trends in VILI research require comprehensive characterization.
Purpose of the Study:
- To systematically evaluate the development, research hotspots, and future directions of ventilator-induced lung injury (VILI) research.
- To characterize the global research landscape and collaborative networks in VILI.
Main Methods:
- Bibliometric analysis of 4,055 VILI-related publications from 2000-2024 retrieved from Web of Science Core Collection.
- Utilized Bibliometrix, VOSviewer, and CiteSpace for visualization and network analyses of publication output, citations, countries, institutions, authors, journals, and keywords.
- Identified research collaborations, influential contributors, knowledge structures, and emerging research themes through keyword co-occurrence, burst detection, and thematic analyses.
Main Results:
- A sustained upward trend in annual publications and citations indicates growing scientific interest in VILI.
- The United States leads in publication output, citations, and international collaborations, with Harvard University as a key institution.
- Key research hotspots include inflammation, oxidative stress, NLRP3 inflammasome activation, barrier dysfunction, mechanotransduction, and precision ventilation strategies, with a shift towards molecular mechanisms and translational interventions.
Conclusions:
- VILI research has expanded significantly over two decades, marked by increased global collaboration and diversified themes.
- Current research focuses on mechanistic investigations of inflammatory pathways and cellular injury, moving beyond clinical ventilation strategies.
- This study provides a comprehensive overview of VILI research's intellectual structure and trajectory, guiding future investigations.
Keywords:
NLRP3 inflammasomeVentilator-induced lung injury (VILI)bibliometric analysisinflammationmechanical ventilationMore Related Videos
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