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Updated: Aug 13, 2026
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
Metal-based putty implant functionalized with copper nanoparticles for bone tissue regeneration
Rethinam Senthil1, Pelluru Geetha Sravanthy1
1Nano-Bioproducts Research Lab (NBRL), Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India.
Abstract:
This study developed and evaluated a sodium alginate/hydroxyapatite/copper nanoparticle (SA/HA/CuNPs) putty implant for bone tissue engineering. The green-synthesized CuNPs product was characterized by UV-Vis, FTIR, XRD, and FESEM analyses. The putty implant exhibited a porous structure, enhanced biomineralization, antioxidant activity, and strong antibacterial effects against gram-positive (22.4 ± 1.2 mm) and gram-negative (19.8 ± 1.0 mm) bacteria. Mechanical testing showed tensile and compressive strengths of 8.6 ± 0.5 MPa and 14.2 ± 0.8 MPa, respectively. Cytocompatibility studies demonstrated >86% cell viability and favorable live/dead staining results. Overall, the SA/HA/CuNP implant showed promising potential for bone regeneration applications.
