Extended Characterisation of the Coding Sequence of the HLA-C*07:101 Allele by Third-Generation Sequencing
Romain Ferru-Clément1, Perrine Augustin1, Pierre Brossard1
1Laboratoire d'Histocompatibilité et Immunogénétique, Etablissement Français du Sang Nouvelle Aquitaine, Poitiers, France.
HLA
|August 13, 2026
Abstract:
HLA-C*07:101 differs from HLA-C*07:04:01:01 by a single nucleotide substitution in codon 35 within exon 2.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
01:29Modern Molecular Taxonomy
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...