Implementation and Evaluation of a Biochemistry Research Skills CURE for First-Year R1 University Students

Area of Science:

• Biochemistry
• STEM Education

Background:

• Course-based undergraduate research experiences (CUREs) improve STEM retention and skills.
• Few CUREs are designed for first-year biochemistry students or offer adaptable frameworks.
• Gains in scientific reasoning and data analysis are crucial for the life sciences workforce.

Purpose of the Study:

• To develop and evaluate a modular CURE for first-year biochemistry undergraduates.
• To integrate computational biochemistry experiments into existing curricula without increasing workload.
• To assess student gains in research skills, scientific communication, and engagement with biochemistry.

Main Methods:

• Developed and implemented the "Introduction to Biochemical Research Skills" CURE.
• Utilized computational biochemistry experiments focusing on protein structure-function relationships.
• Employed established assessments and student reflections to evaluate learning outcomes.

Main Results:

• Students reported enhanced practical research and scientific communication skills.
• Participants gained exposure to problem-solving techniques and iterative hypothesis testing.
• Engagement with protein structure-function research increased student excitement about biochemistry.

Conclusions:

• The developed CURE effectively enhances first-year biochemistry students' research skills and engagement.
• The modular, computational approach allows for scalable implementation and adaptation by instructors.
• Further research will explore the course's longitudinal impact on academic performance and research progression.