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Updated: Aug 14, 2026

Human Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay
Published on: April 5, 2019
Anti-Zic4- and Anti-NMDAR-Positive Patients and Their Correlation with Clinical Course and Image Diagnostic
Milen Hristozov1,2, Krasimir Shukerski3,4, Antoniya Yaneva5
1Department of Medical Microbiology and Immunology "Prof. Dr. Elissay Yanev", Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Paraneoplastic neurological syndromes (PNSs) can precede tumor diagnosis. This study links anti-Zic4 to paraneoplastic cerebellar degeneration and anti-NMDAR to autoimmune encephalitis, highlighting the need for long-term patient follow-up.
Area of Science:
- Neurology
- Immunology
- Oncology
Background:
- Paraneoplastic neurological syndromes (PNSs) are rare disorders associated with cancer, often preceding tumor diagnosis.
- Early recognition of PNSs is crucial for timely cancer treatment and improved patient outcomes.
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