Sulfonamides Inhibit Root Growth via ROS-Triggered and MPK3/6-Modulated Synthesis of the Ethylene Precursor ACC

Ting He1, Zixuan Zhao1, Xinyi Liu1

  • 1Key Laboratory of Jiangxi Province for Biological Invasion and Biosecurity, School of Life Sciences, Jinggangshan University, Ji'an 343009, China.

Biology
|August 13, 2026
PubMed
Summary

Sulfonamide antibiotics inhibit plant root growth by disrupting the reactive oxygen species (ROS)-ethylene signaling pathway. This involves transcriptional activation of ACS1 and post-translational stabilization of ACS2/ACS6, leading to root growth inhibition.

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