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Long-Term Corticosteroid-Induced Ocular Hypertension Model Produced by Topical Rinderon-A Ointment Application
Hsin-Lin Cheng1, Yung-Chang Yen2,3, Jiann-Jou Yang1,4
1Department of Biomedical Sciences, Chung Shan Medical University, Taichung 40201, Taiwan.
Biology
|August 13, 2026
Summary
Prolonged corticosteroid use can cause high intraocular pressure (IOP), leading to glaucoma. This study developed a rat model using Rinderon-A ointment to investigate this condition and test treatments.
Area of Science:
- Ophthalmology
- Pharmacology
- Animal Models
Background:
- Prolonged corticosteroid therapy is linked to elevated intraocular pressure (IOP).
- Untreated ocular hypertension can lead to iatrogenic glaucoma and irreversible blindness.
- Reliable animal models are crucial for studying corticosteroid-induced ocular hypertension and therapeutic interventions.
Purpose of the Study:
- To establish a simple, non-invasive rat model for corticosteroid-induced ocular hypertension.
- To investigate the sustained effects of topical corticosteroid application on IOP in rats.
- To provide a reproducible platform for future research on ocular hypertension treatments.
Main Methods:
- Topical application of Rinderon-A ointment to rats.
- Weekly intraocular pressure (IOP) measurements using a Tono-Pen over 11 weeks.
- Monitoring IOP in conscious rats throughout the experimental period.
Main Results:
- Rinderon-A treatment induced sustained bilateral IOP elevation in rats.
- An initial IOP increase was observed at week 1 (28.4 ± 1.5 mmHg).
- Maximal mean IOP reached 31.2 ± 0.7 mmHg at week 10, demonstrating a consistent hypertensive response.
Conclusions:
- A reproducible and non-invasive rat model for corticosteroid-induced ocular hypertension was successfully established.
- This model effectively simulates sustained IOP elevation caused by topical corticosteroid use.
- The model serves as a valuable platform for investigating therapeutic strategies for corticosteroid-associated ocular hypertension.
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