Related Experiment Video
Updated: Aug 14, 2026
07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Intestinal Flora and Myocarditis: Potential Mechanisms and Therapeutic Strategies Affecting Disease Progression and
Qianyi Liu1, Dan Huang1,2,3,4, Kun Huang1,2,3,4
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
International Journal of Molecular Sciences
|August 13, 2026
Summary
Myocarditis, an inflammatory heart condition, is linked to gut bacteria imbalances. Targeting the gut microbiome may offer new therapeutic strategies for this challenging disease.
Area of Science:
- Cardiology
- Immunology
- Microbiology
Background:
- Myocarditis is a serious heart condition with poor outcomes.
- Gut microbiota dysbiosis is increasingly linked to myocarditis development.
Purpose of the Study:
- To explore the gut-myocarditis axis.
- To highlight key mechanisms and potential therapeutic strategies.
Main Methods:
- Review of existing literature on gut microbiota and myocarditis.
- Analysis of pathways linking gut dysbiosis to cardiac inflammation.
Main Results:
- Gut microbial alterations are evident in myocarditis patients and models.
- Mechanisms include compromised gut barrier, altered metabolites (TMAO, SCFAs), and molecular mimicry.
- Therapeutic strategies like FMT, probiotics, and dietary changes are discussed.
Conclusions:
- The gut microbiome significantly influences myocarditis.
- Targeting the gut-myocarditis axis offers promising therapeutic avenues.
- Further clinical validation is required for proposed treatments.
Related Concept Videos
01:14Myocarditis III: Medical Management
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
01:21Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
01:22Myocarditis IV: Nursing Management
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
01:18Endocarditis III: Medical Management
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...