Novel and emerging cutaneous soft tissue tumours

Molecular advances have expanded the spectrum of cutaneous soft tissue tumours, leading to the recognition of several recently described entities with distinct genetic drivers. This review outlines the defining histopathological, immunophenotypic and molecular features of hybrid superficial ALK-rearranged myxoid spindle cell neoplasm/epithelioid fibrous histiocytoma, superficial neurocristic tumour, ALK-rearranged epithelioid vascular neoplasm and MITF pathway-activated melanocytic tumour. Key diagnostic features and differential considerations are highlighted, with attention to areas of morphological overlap and current gaps in biological characterization. This synthesis aims to facilitate accurate recognition and classification of these emerging tumours in routine dermatopathology practice.