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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Apr 1, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

TPM4::ALK Rearranged Cutaneous Epithelioid Vascular Tumor: A Case Report.

Jenny Shuaijin Wang¹, Steven D Billings², Shira Ronen²

¹Department of Pathology & Laboratory Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.

Journal of Cutaneous Pathology

|March 31, 2026

Summary

This summary is machine-generated.

A rare epithelioid vascular tumor with a TPM4::ALK fusion was identified in a young boy. This sixth reported case, the second with this specific fusion, showed no recurrence after surgical removal.

Area of Science:

Oncology
Pathology
Genetics

Background:

Epithelioid vascular tumors encompass a spectrum from benign to malignant entities.

Keywords:

ALK TPM3 TPM4 epithelioid vascular tumor

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A subset of these tumors exhibits epithelioid morphology and TPM3/4::ALK fusions.

This report details the sixth case of such a tumor, with a specific focus on the TPM4::ALK fusion.