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How Functional Variants Reconfigure the Rac2 Conformational Landscape

Nurit Haspel1, Hyunbum Jang2, Ruth Nussinov2,3

  • 1Department of Computer Science, University of Massachusetts Boston, Boston, Massachusetts02125, United States.

The Journal of Physical Chemistry. B
|August 13, 2026
PubMed
Summary

Mutations in Rac2 GTPase, D57N (loss-of-function) and E62K (gain-of-function), disrupt immune function through distinct mechanisms. Rac2D57N remains inactive, while Rac2E62K is constitutively active, both hindering p50-RhoGAP regulation.

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