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The use of "clear" enzyme control materials
The American Journal of Medical Technology
|March 1, 1979
Summary
Clear enzyme controls offer superior precision and stability for laboratory quality control compared to traditional turbid sera. These findings support their use in daily enzyme assays for improved diagnostic accuracy.
Area of Science:
- Clinical Chemistry
- Biotechnology
- Laboratory Medicine
Background:
- Traditional lyophilized control sera can be turbid, potentially affecting assay accuracy.
- Commercially produced clear enzyme controls are available in multiple concentrations.
Purpose of the Study:
- To compare the suitability of clear enzyme controls versus turbid control sera for laboratory quality control.
- To evaluate enzyme control performance based on turbidity, precision, and stability.
Main Methods:
- Turbidity measurements were taken for both control types.
- Daily enzyme assays were performed over 30 days to assess day-to-day precision.
- Stability was evaluated for reconstituted and frozen controls over 10 and 30 days.
Main Results:
- Clear enzyme controls exhibited lower turbidity.
- Both control types showed acceptable day-to-day precision.
- Clear controls demonstrated superior stability when frozen for extended periods.
Conclusions:
- Clear enzyme controls are a viable alternative to traditional turbid sera for quality control.
- The enhanced stability of clear controls supports their use in routine laboratory diagnostics.
- Clear controls offer improved performance characteristics for enzyme activity monitoring.