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Updated: Aug 16, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Fe(III)-Catalyzed Cascade C-H Functionalization/cycloaddition of ortho-Alkynyl Arylhydrazides: Facial Access to
Tao Zhu1, Lechi Zhang1, Tao Song2
1School of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi341000, P. R. China.
Abstract:
A synthetic protocol for the construction of 3,4-disubstituted cinnoline scaffolds was described, which allowed for the transformation of ortho-alkynyl arylhydrazides via iron-catalyzed cascade C-H functionalization/cycloaddition. Furthermore, the practical utility of this method had been validated by easily scale-up synthesis, substrates derived from bioactive molecules and versatile derivatization of the target products. Mechanistic studies revealed that the reaction possibly proceeds via twice iron-mediated single-electron transfer (SET) processes. Furthermore, the resulting 3,4-disubstituted cinnolines exhibited significant anti-inflammatory effects from LPS stimulation experiment.
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