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![[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-Mediated Selective Cyanofluoroolefination of Diazo Compounds with TMSCF2CN
Lu Yang1,2, Kaidi Zhu2, Rumin Huang2
1Henan Institute of Advanced Technology, Zhengzhou University, 97 Wenhua Road, Zhengzhou, Henan450003, China.
Abstract:
Fluorinated alkene-containing molecules are of growing importance in pharmaceutical and agrochemical applications. Herein, we describe a copper-mediated defluorinative coupling of TMSCF2CN with diazo compounds under mild conditions, providing straightforward access to highly E/Z-selective cyanofluoroalkenes. This method features broad functional group compatibility and is amenable to the late-stage functionalization of complex molecules. Furthermore, the presence of the cyano group offers a versatile handle for further derivatization of the resulting cyanofluoroalkene products.
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