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Pan-Cancer Landscape of Interferon-Induced Protein 35 and Its Tumor-Promoting Role in Breast Cancer
Yudong Mu1, Tao Zhang2, Lin He3
1Center for Translation Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Department of Clinical Laboratory, Shaanxi Provincial Tumor Hospital, Xi'an, Shaanxi, China.
The Journal of Surgical Research
|August 14, 2026
Summary
Interferon-induced protein 35 (IFI35) promotes breast cancer (BRCA) progression by increasing cell proliferation and migration. This study highlights IFI35 as a potential therapeutic target for BRCA treatment.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Interferon-induced protein 35 (IFI35) regulates immune responses but its role in cancer, especially breast cancer (BRCA), is not fully understood.
- This study investigates the expression, prognostic value, and functional significance of IFI35 in BRCA and other cancers.
Purpose of the Study:
- To determine the pan-cancer expression profile and prognostic implications of IFI35.
- To elucidate the functional role and clinical significance of IFI35 in breast cancer (BRCA).
Main Methods:
- Utilized public databases (TCGA, CPTAC) for expression and prognostic analysis.
- Validated IFI35 protein expression in BRCA via immunohistochemistry.
- Assessed IFI35 function in BRCA cell proliferation, migration, invasion, and apoptosis using in vitro and in vivo models.
Main Results:
- IFI35 is significantly upregulated in multiple cancers, notably BRCA, and associated with poorer survival.
- Elevated IFI35 correlates with increased immune cell infiltration and cancer-associated fibroblasts.
- IFI35 knockdown suppressed BRCA cell growth and promoted apoptosis; in vivo studies confirmed reduced tumor growth.
Conclusions:
- IFI35 overexpression drives BRCA progression.
- IFI35 represents a potential therapeutic target for breast cancer (BRCA).
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