Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Premature menopause. I. Etiology.

C B Coulam, R J Ryan

    American Journal of Obstetrics and Gynecology
    |March 15, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Premature menopause may be an autoimmune disorder. Studies show increased antibodies to ovarian tissue in women with premature cessation of menses before age 35, suggesting an autoimmune cause.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chromatin intact human sperm recovery is higher following glass wool column filtration as compared with density gradient centrifugation.

    Andrologia·2011
    Same author

    Convulsions occurring under anesthesia; analysis of six cases.

    American journal of surgery·2010
    Same author

    P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure.

    Fertility and sterility·2008
    Same author

    Vascular endothelial growth factor gene polymorphism and implantation failure.

    Reproductive biomedicine online·2008
    Same author

    Discordance among blastomeres renders preimplantation genetic diagnosis for aneuploidy ineffective.

    Journal of assisted reproduction and genetics·2007
    Same author

    p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure.

    Reproductive biomedicine online·2006

    Area of Science:

    • Reproductive Immunology
    • Endocrinology

    Background:

    • Premature menopause (PM) is often classified as an organ-specific autoimmune disorder.
    • Evidence suggests circulating antibodies to ovarian tissue may play a role in PM.

    Purpose of the Study:

    • To investigate the presence and significance of autoantibodies against ovarian tissue in women diagnosed with premature menopause syndrome.

    Main Methods:

    • Sera from 15 women with PM (menses ceased before 35) were analyzed for antibodies targeting ovarian proteins.
    • Ovarian proteins were extracted, radiolabeled with 125I, and incubated with patient and control sera.
    • Antibody binding was quantified using goat antihuman gamma-globulin precipitation and radioactive measurement.

    Main Results:

    Related Experiment Videos

  • Women with premature menopause syndrome exhibited elevated levels of circulating antibodies that bind to ovarian tissue compared to control subjects.
  • These findings correlate with documented hormonal changes in PM, including increased gonadotropin and decreased estrogen.

    • Conclusions:

    • The results strongly suggest that circulating autoantibodies targeting ovarian tissue are implicated in the etiology of premature menopause syndrome.
    • This supports the classification of premature menopause as an autoimmune condition.