[Genomic and Epigenomic Research on Brain Tumors]

All cancers, including brain tumors, arise from driver genomic and epigenomic alterations and evolve through the sequential acquisition of additional abnormalities. The emergence of next-generation sequencing technologies in the early 2000s enabled rapid and large-scale genomic and epigenomic analyses, leading to substantial advances in our understanding of the molecular pathogenesis of brain tumors. Consequently, driver alterations with potential therapeutic relevance have been progressively identified. Furthermore, continued technological innovations in sequencing technologies have consistently expanded our insights into brain tumor biology. In this review, we summarize recent findings from omics studies on brain tumors and discuss their biological and clinical implications.