[Peripheral Autonomic Neuropathy in α-Synucleinopathy]

Parkinson disease and pure autonomic failure are α-synucleinopathies that lead to peripheral autonomic neuropathy. These autonomic disturbances include well-known symptoms, such as orthostatic hypotension and constipation, and often overlooked symptoms, including supine hypertension and gastroparesis. This article describes the characteristics of diverse peripheral autonomic symptoms of α-synucleinopathies and discusses therapeutic interventions available in daily clinical practice and their impact on prognosis, in the absence of established disease-modifying drugs.