Circ_0070190 suppresses the malignant progression of cervical cancer by sponging miR-587

The purpose of this study is to explore the function of circ_0070190 in cervical cancer (CC) as well as its regulatory mechanism through sponging miR-587. RT-qPCR was applied to detect the expression of circ_0070190 and miR-587 in CC tissues, corresponding adjacent normal tissues, and CC cell lines. The impact of circ_0070190 on the proliferative capacity of CC cells was evaluated using CCK-8, while the Transwell assay was utilized to determine its effect on cell migration and invasion. The targeted binding relationship between circ_0070190 and miR-587 was confirmed by dual luciferase reporter gene assay and RNA co-immunoprecipitation (RIP) assay. The expression of circ_0070190 in CC tissues was markedly downregulated compared with that in adjacent normal tissues. Additionally, low expression of circ_0070190 were associated with positive lymph node metastasis and higher FIGO stage, and the Kaplan-Meier curve and Cox analysis indicated that low circ_0070190 level predicted a shorter survival period of 5 years for CC patients. Overexpression of circ_0070190 remarkably suppressed the proliferation, migration, and invasion of CC cells. Importantly, miR-587 is a direct target of circ_0070190, the suppressive effect of circ_0070190 was abrogated by miR-587 mimic. Circ_0070190 might be a prognostic marker for CC and exerts an inhibitory effect on the malignant progression by sponging miR-587. The circ_0070190/miR-587 regulatory axis may offer a potential novel target for the targeted therapy of CC.