Related Experiment Video
Updated: Aug 21, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Hyperglycemic microenvironment-driven periodontal tissue defects: pathogenic mechanisms and therapeutic advances
Shuyu Wang1,2, Wenjun Zhang1,2, Yudong Guo1,2
1Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, China.
Background:
In recent years, the prevalence of diabetes mellitus and periodontal disease has been on the rise, which has drawn scholars' attention to the association between diabetes mellitus and periodontitis.
Main Body:
Studies have demonstrated that a hyperglycemic microenvironment can notably increase the incidence of periodontitis and the severity of bone loss, impair the regenerative capacity of periodontal tissues, and thereby affect the therapeutic effect of periodontitis. This paper comprehensively reviews the latest research progress regarding the impact of diabetes mellitus on periodontitis and summarizes the current therapeutic strategies for diabetes complicated with periodontitis, including both traditional therapeutic methods and novel therapeutic approaches.
Conclusion:
In conclusion, this review provides a systematic overview of the interaction between diabetes and periodontitis as well as related treatments, laying a foundation for subsequent clinical research and practice.
Related Concept Videos
The Oral Microbiota
Diabetic Retinopathy
Hyperglycemia
Type II Diabetes II: Pathophysiology
Diabetic Foot Ulcer
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

