Related Experiment Video
Updated: Aug 21, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
A Case of Unresectable Hepatocellular Carcinoma Responding to Durvalumab Plus Tremelimumab after Lenvatinib Treatment
Saki Sueda1, Tomokazu Kawaoka1, Yasutoshi Fujii2
1Department of Gastroenterology, Hiroshima University Hospital, Japan.
Abstract:
We report a case of unresectable hepatocellular carcinoma (HCC) that responded to durvalumab plus tremelimumab after disease progression during atezolizumab monotherapy and intolerance to lenvatinib. A 74-year-old man with a Child-Pugh A liver function developed multifocal HCC that was refractory to prior therapies. Tumor markers transiently increased after durvalumab plus tremelimumab initiation, followed by normalization and radiological tumor shrinkage without any new lesions. This response may be associated with lenvatinib-mediated modulation of the tumor microenvironment and/or immune activation induced by CTLA-4 blockade.
Related Concept Videos
Treatment Resistent Cancers
Treatment Resistant Cancers
