Related Experiment Video
Updated: Aug 22, 2026

Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
A quasi-experimental study of abortion rates following gestational age limit changes in Japan
Yuko Yanagawa1, Aurelie Piedvache1, Yusuke Okubo1
1Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
Abstract:
The relationship between of legislative changes in abortion regulations on women's decision-making remains understudied. In 1991, Japan reduced the gestational limit for abortion from 24 to 22 weeks of pregnancy. Here, using national data on abortions, stillbirths and live births at ≥12 weeks from 1989 to 1994 (n = 7,364,783), we examined the association of the change with abortion incidence rate and cumulative incidence between 12 and 27 weeks using quasi-experimental interrupted time-series and regression discontinuity analyses. After the change, incidence rates increased at 20 weeks (incidence rate ratio (IRR) 1.28, 95% confidence interval (CI), 1.15-1.43) and 21 weeks (IRR 1.33, 95% CI, 1.18-1.50), while decreasing at 22 weeks (IRR 0.25, 95% CI, 0.21-0.30, P < 0.001) and 23 weeks (IRR 0.07, 95% CI, 0.06-0.10, P < 0.001), and no meaningful changes for ≤19 or ≥24 weeks. Cumulative incidence decreased only for women at 19-23 weeks. In conclusion, the legislative change shifted abortions to earlier gestational ages, and was associated with fewer abortions among women who had reached 19th week of pregnancy.
Related Concept Videos
Nondisjunction
Meiosis I
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Oogenesis
Regression Toward the Mean