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Updated: Aug 24, 2026

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
NiH Catalysis-Enabled Synthesis of 4-Arylpiperidines from Pyridines and Aryl Iodides
Xinshuai Liu1, Baoye Zhang1, Mingxia Gao1
1Hebei Key Laboratory of Organic Functional Molecules, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang050024, China.
Abstract:
4-Arylpiperidines are prominent motifs in bioactive molecules and drugs. However, general synthetic strategies for their construction remain underexplored. We herein describe a route to 4-arylpiperidines from simple pyridines and aryl iodides. NiH-catalyzed regioselective hydroarylation of 1,2-dihydropyridines served as the key step to access various 4-aryl tetrahydropyridines, which were readily converted to diverse 4-arylpiperidines via hydrogenation or functionalization of the enamine double bond. This protocol features direct use of iodoarenes as arylating reagents, mild conditions, and excellent functional group tolerance.
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