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![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Base-Controlled Dual Pd Catalysis Enabling Tunable Tandem C(sp3)-H Cyclopalladation-Annulation and 6-endo-trig Heck
Upamanyu Das1,2, Pritam Roy1,2, Saumen Hajra1,2
1Centre of BioMedical Research (CBMR), Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow, Uttar Pradesh226014, India.
None:
Harnessing the divergent reactivity of multifunctional substrates under palladium catalysis offers a powerful route to molecular complexity. A base-controlled, switchable dual reactivity of a single Pd catalyst-ligand system toward a designed haloarene substrate has been established, enabling either tandem C(sp3)-H cyclopalladation-annulation or 6-endo-trig Heck cyclization. Precise base-solvent selection directs access to diverse naphthalene, dihydronaphthalene, and (hetero)polyarene scaffolds, including bioactive natural product cores and advanced materials.
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