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Updated: Aug 24, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Defluorinative Coupling of Trifluoromethyl Arenes via Consecutive Photoinduced Electron Transfer
Mengqi Zhu1, Liang Chen1, Dong-Fang Jiang2
1College of Chemistry, Xiangtan University, Xiangtan, Hunan411105, China.
None:
A visible-light-induced selective defluorinative cyclization reaction of quinazolinones bearing unactivated alkene moieties with a variety of trifluoromethylarenes is reported. This protocol features mild reaction conditions and exhibits broad substrate compatibility, accommodating diverse unactivated alkenes as well as electron-deficient trifluoromethylarenes, thus enabling the efficient construction of difluorinated quinazolinone derivatives. Mechanistic investigations reveal that the transformation proceeds through a consecutive photoinduced electron transfer (ConPET) pathway, which is crucial for overcoming the thermodynamic barrier associated with C-F bond activation under visible-light irradiation.
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