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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
Published on: June 26, 2019
Impact of lineage-specific epidermal growth factor receptor mutations in cancer
Amy Rios1,2,3, Kimberly A Jorge2,3,4, Gizelle G Ramirez2,3,4
1Molecular Biology Interdepartmental Doctoral Program, University of California , Los Angeles, CA, 90095, USA.
Abstract:
The epidermal growth factor receptor, or EGFR, is one of the most frequently altered oncogenes in human cancer and is a critical therapeutic target. EGFR alterations span a broad spectrum, including gene amplification, point mutations, truncations, in-frame insertions or deletions, and fusions, yet their mutational distribution is cancer type-specific. This distribution impacts the effectiveness of EGFR-targeted therapies across EGFR-mutant cancers. This review will cover what is currently known about the EGFR-driven cancer landscape in the following cell lineages: lung, brain, colon, breast and bladder. This article is part of the discussion meeting issue 'Epidermal growth factor receptor after 40 years'.
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