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Substantial under-detection of human rabies cases in the United States

Younjung Kim1,2, Christl A Donnelly1,2

  • 1Department of Statistics, University of Oxford, Oxford, UK.

Communications Health
|August 31, 2026
PubMed

Keywords:
DiseasesHealth careMedical researchMicrobiology

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Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...