Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates

Stereoselective binding of the enantiomers of four closely related N-methyl-barbiturates to human, bovine, and rat serum albumin.

Archiv der Pharmazie·1996

Influence of albumin concentration, albumin species, pH and temperature on the stereoselectively different binding of (S)-(+)- and (R)-(-)-1-methyl-5-phenyl-5-propyl-barbiturate to serum albumin.

Arzneimittel-Forschung·1995

Propofol binding to human blood proteins.

Arzneimittel-Forschung·1995

[1,5-Benzodiazepines. 2. Diametrically opposite central nervous system actions of the two stereoisomers of 3,3-dialkyl-1,5-benzodiazepine-2,4-diones].

Archiv der Pharmazie·1995

HPLC assay for atropine in serum and protein solutions after in vitro addition of the tropane alkaloid.

Methods and findings in experimental and clinical pharmacology·1994

Stereoselective differences in the binding of N-methylated barbiturates to human serum albumin.

Arzneimittel-Forschung·1994

Effects of vitamin B1/B6/B12 complex on methotrexate-induced hepatorenal toxicity in a short-term acute rat model.

Naunyn-Schmiedeberg's archives of pharmacology·2026

The global surge of cocaine use disorder: a 30-year burden analysis from the GBD 2021.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Combined rituximab and magnesium acetyl taurate therapy attenuates neurodegeneration via ERK/c-JNK/P38MAPK signaling modulation in methylmercury-induced amyotrophic lateral sclerosis-like neurotoxicity.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Mapping the knowledge landscape and identifying frontiers of mitochondrial dysfunction in sepsis-associated acute kidney injury: a four-decade bibliometric and visualized analysis.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Association of 24-hours net positive fluid balance with log-transformed vancomycin trough concentrations in the early phase of therapy among critically ill patients.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Pharmacological features of mesoionic compounds: antitumoral effects and bioenergetic disruption of sydnones and 1,3,4-thiadiazolium derivatives.

Naunyn-Schmiedeberg's archives of pharmacology·2026

Uncovering potent natural products against Sars-Cov-2 main protease using structure-based virtual screening and simulation studies.

In silico pharmacology·2026

[Meta-path-enhanced multimodal heterogeneous hypergraph Transformer for herbal compound-target interaction prediction].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

[Antidepressant mechanism of essential oil from Schizonepeta tenuifolia based on 5-HT1AR/cAMP/PKA signaling pathway].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

[Research progress in modern scientific connotation of compatibility of TCM compound prescriptions based on supramolecular assembly].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

Determinants of Etoposide Hypersensitivity Span all of the Top2 alpha Catalytic Domains.

Journal of molecular biology·2026

Natural product cephalomannine suppresses triple-negative breast cancer progression by targeting VEGFR1 signaling.

Tissue & cell·2026

Related Experiment Videos

Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates

Related Concept Videos

Stereoselective binding of the enantiomers of four closely related N-methyl-barbiturates to human, bovine, and rat serum albumin.

Influence of albumin concentration, albumin species, pH and temperature on the stereoselectively different binding of (S)-(+)- and (R)-(-)-1-methyl-5-phenyl-5-propyl-barbiturate to serum albumin.

Propofol binding to human blood proteins.

[1,5-Benzodiazepines. 2. Diametrically opposite central nervous system actions of the two stereoisomers of 3,3-dialkyl-1,5-benzodiazepine-2,4-diones].

HPLC assay for atropine in serum and protein solutions after in vitro addition of the tropane alkaloid.

Stereoselective differences in the binding of N-methylated barbiturates to human serum albumin.

Effects of vitamin B1/B6/B12 complex on methotrexate-induced hepatorenal toxicity in a short-term acute rat model.

The global surge of cocaine use disorder: a 30-year burden analysis from the GBD 2021.

Combined rituximab and magnesium acetyl taurate therapy attenuates neurodegeneration via ERK/c-JNK/P38MAPK signaling modulation in methylmercury-induced amyotrophic lateral sclerosis-like neurotoxicity.

Mapping the knowledge landscape and identifying frontiers of mitochondrial dysfunction in sepsis-associated acute kidney injury: a four-decade bibliometric and visualized analysis.

Association of 24-hours net positive fluid balance with log-transformed vancomycin trough concentrations in the early phase of therapy among critically ill patients.

Pharmacological features of mesoionic compounds: antitumoral effects and bioenergetic disruption of sydnones and 1,3,4-thiadiazolium derivatives.

Uncovering potent natural products against Sars-Cov-2 main protease using structure-based virtual screening and simulation studies.

[Meta-path-enhanced multimodal heterogeneous hypergraph Transformer for herbal compound-target interaction prediction].

[Antidepressant mechanism of essential oil from Schizonepeta tenuifolia based on 5-HT1AR/cAMP/PKA signaling pathway].

[Research progress in modern scientific connotation of compatibility of TCM compound prescriptions based on supramolecular assembly].

Determinants of Etoposide Hypersensitivity Span all of the Top2 alpha Catalytic Domains.

Natural product cephalomannine suppresses triple-negative breast cancer progression by targeting VEGFR1 signaling.

Related Experiment Videos

Stereochemical dependence of pharmacological activity in a series of optically active N-methylated barbiturates

Related Concept Videos

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