Observed pre-intervention and non-intervention ventricular growth trajectories in neonates with severe intraventricular hemorrhage and post-hemorrhagic ventricular dilation
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Published on: December 22, 2023
Garrett Gianneschi1, Michael Lance Christian2, Hira Arif3
1Department of Neurology, Division of Child Neurology, Rutgers New Jersey Medical School, Newark, NJ, USA. gbg30@rutgers.edu.
Background:
Post-hemorrhagic ventricular dilation (PHVD) after severe intraventricular hemorrhage (SIVH) remains incompletely characterized.
Objective:
To quantify ventricular expansion after SIVH and explore associations with bilateral hemorrhage burden and mortality.
Methods:
We retrospectively reviewed 43 neonates with SIVH-associated PHVD cared for in a single NICU from 2010 to 2025. Serial cranial ultrasounds were measured for ventricular index (VI) and anterior horn width (AHW). Post-intervention measurements were censored. An exploratory bilateral hemorrhage-burden score summed maximum right and left IVH grades.
Results:
VI and AHW increased significantly with PMA, each at 0.105 mm/day. High composite IVH score (7-8) was associated with faster VI and AHW expansion than low score (3-6), and with higher mortality.
Conclusions:
Ventricular enlargement progressed approximately linearly during observed pre-intervention/non-intervention follow-up. Bilateral hemorrhage-burden scoring may improve risk stratification, but findings are exploratory.
