Immunoscore as a prognostic marker in colorectal cancer

Introduction: Colorectal cancer is a leading cause of morbidity and mortality worldwide. Immunoscore provides important prognostic information in early-stage colorectal cancer, beyond traditional TNM staging. Aim: To investigate the Immunoscore in early-stage colorectal cancer and its prognostic value. Patients and methods: A retrospective pilot cohort of 35 patients was evaluated for recurrence, survival, toxicity, and clinical correlations with Immunoscore. Results: High Immunoscore was associated with better outcomes, including zero recurrence. Immunoscore showed trends by tumor location, with stronger associations in younger patients. There was no correlation with carcinoembryonic antigen levels. Conclusion: Our findings support the incorporation of Immunoscore into future colorectal cancer staging models.