Related Experiment Video
Updated: Sep 3, 2026

Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Dynamic process of lipid deterioration in hickory: Mechanism analysis of metabolic imbalance, membrane damage and
Chongchong Wang1, Yajun Bi1, Weihong Min2
1State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, China; College of Food and Health, Zhejiang A&F University, No. 666 Wusu Road, Linan District, 311300 Hangzhou, Zhejiang Province, China.
Abstract:
Hickory nuts were nutrient-rich but were prone to storage deterioration due to high fat content. In this study, using integrated lipidomics and transcriptomics, we profiled 2159 lipids and 5952 differentially expressed genes in hickories stored at 4 °C and 35 °C for 90 days. Results showed that oxidative stress decreased iodine value and increased anisidine and conjugated diene values, reflecting reduced lipid unsaturation and oxidation product accumulation. Upregulation of TGL4 and PLD1_2 accelerated triglyceride and phospholipid hydrolysis. However, ACAA1 downregulation inhibited free fatty acid catabolism generated during this process, which promoted off-flavor generation and anomalous triglyceride accumulation via re-esterification. Additionally, downregulation of DGKs and FAB2 caused the gradual accumulation of LPCs and Cer, disrupting sphingolipid balance and membrane integrity. This multi-omics study elucidates how dysregulation of lipid repair and sphingolipid disruption lead to accelerated oxidation during hickory storage. The findings supported Sustainable Development Goal 12.3 by informing strategies to reduce postharvest nut losses.
Related Concept Videos
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Asymmetric Lipid Bilayer
Assembly of the Lipid Bilayer in the ER
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
Mitochondrial Membranes
Lipid Digestion

