Nanotechnologies in musculoskeletal health

Bone and muscle are two strictly linked tissue due both for their nearness but also for their tight coupled activity. Due to the increase of longevity it is important to work on these tissues to guarantee locomotion, thus it is important to identify potential therapeutic target for their health. Thus, together with the classical approaches, new modalities have been identified and in particular those involving nanotechnologies.

to review the role of nanotechnologies in musculoskeletal health.

PubMed search using as keywords nanotechnologies combined with musculoskeletal, bone and muscle.

the key role of calcium in the nanotechnological approach in bone health, as in this tissue this ion is presented at high percentage, and thanks to its characteristics also bisphosphonates can be assembled with nanoparticle to bind specifically bone. The role of lipid-based nanoparticles for bone and muscle homeostasis is revised. Polymeric nanoparticles are also revised. Positive and toxic effects were also reported. This overview is important for future development in musculoskeletal health.