Related Experiment Videos

Association Between Early Coagulation Disorder and All-Cause Mortality in Critically Ill Stroke Patients: A

Yezhen Qin1, Xiaoqin Han1, Min Xia1

  • 1Department of Emergency Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|September 2, 2026
PubMed

BackgroundThe clinical relevance of the early coagulation disorder (ECD) score, derived from platelet count, international normalized ratio (INR), and activated partial thromboplastin time (APTT), in patients with stroke remains unclear. This study aimed to evaluate the association between ECD score at intensive care unit (ICU) admission and all-cause mortality (ACM) in patients with stroke.MethodsThis retrospective cohort study utilized data from the MIMIC-IV database. The primary outcome was 30-day all-cause mortality; secondary outcomes included 90-day and 1-year all-cause mortality. Kaplan-Meier curves and multivariable Cox models were used to assess associations between ECD scores and outcomes. Subgroup analyses and interaction tests were conducted to verify robustness.ResultsAmong 5753 participants (median age 70.97; 52.03% male), the 30-day mortality rate was 17.17%. Kaplan-Meier analysis showed significantly higher mortality in patients with ECD (log-rank P < 0.01). Multivariable analysis indicated increased risks of mortality within 30 days in patients with ECD (HR = 1.374, 95% CI: 1.174-1.608) and those with ECD scores of 5-6 (HR = 1.374, 95% CI: 1.011-1.868) compared to those without ECD or with a score of 0, respectively. Subgroup analyses supported these findings.ConclusionElevated ECD scores are associated with increased mortality in critically ill patients with stroke. Comprehensive coagulation assessment may improve clinical management and risk assessment.Clinical trial registration: not applicable.

Keywords:
ACMMIMIC-IVassociationcoagulation disorderstroke

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.