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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Neuroblastoma
Meera Kotagal1, Christa N Grant2, Erin G Brown3
1Division of Pediatric General and Thoracic Surgery, Department of Surgery, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Abstract:
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor. The most common location for development of NB is in the adrenal glands, but primary tumors may develop along the developmental pathway of neural crest progenitor cells. NB may vary in severity and prognosis from low-risk congenital neuroblastic lesions to aggressive high-risk neuroblastoma. Therapy is risk-based with intensification of therapy for those at greater risk and de-escalation for patients with lower risk tumors. Surgical resection has a critical role in local control of NB for the most optimal outcome.
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