[Should medications be taken with food ? Practical guidance on administration timing]

Through physiological mechanisms and direct interactions, food intake influences the absorption and bioavailability of orally administered medications, with clinical consequences in terms of both efficacy and tolerability. This article provides a practical overview of how commonly prescribed medications should be taken in relation to meals, distinguishing between those that must be administered on an empty stomach, away from meals, or with food. Some medications require strict administration conditions, while others allow greater flexibility. An individualized approach is therefore essential, taking into account the risk of intolerance, to optimize the dosing schedule and promote good therapeutic adherence.