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Updated: Sep 4, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Efficacy of Leukocyte Platelet Rich Fibrin (L-PRF) Versus L-PRF with βeta Tri-calcium Phosphate (β-TCP) Bone Graft in
George Samyo Stephenson1, Deepak Abraham Pandyan1, Satheesh Chandran1
1Dept. of Oral and Maxillofacial Surgery, Madha Dental College and Hospital, Chennai, India.
Background:
Mandibular third molar removal surgically exhibits severe pain, edema, limitation in mouth opening, impaired wound healing, and delayed bone formation postoperatively.
Purpose:
To compare the effectiveness of leukocyte platelet-rich fibrin (L-PRF) and L-PRF with β-Tricalcium phosphate (β-TCP) bone graft on postoperative outcomes after mandibular impacted third molar surgery.
Materials And Method:
This split-mouth double-blinded randomized controlled study was conducted on 100 patients, who presented for bilateral extraction of mandibular impacted third molars. Group I included 50 patients who were subjected to L-PRF, and group II included 50 patients who were subjected to L-PRF with β-TCP in the extracted socket after removal of the mandibular third molar. The surgical site bleeding was assessed intraoperatively. The pain, swelling, and trismus were evaluated on the 1st, 3rd, and 7th postoperative days. Wound healing was evaluated on the 3rd and 7th postoperative days, and bone density was assessed on the 3rd postoperative month using cone beam computed tomography (CBCT).
Results:
Group II patients experienced reduced surgical site bleeding, less postoperative swelling, maximum mouth opening, and improved bone regeneration (p Value< 0.05). Group I patients exhibited faster wound healing and less postoperative pain (p< 0.05).
Conclusion:
The results of our study indicate that L-PRF combined with β-TCP remains an excellent and promising biocompatible material for achieving better postoperative outcomes compared to L-PRF alone.