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Updated: Sep 5, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Screening for Colorectal Cancer with Stool Tests
Adam L Urback1, Seth D Crockett2
1Division of Internal Medicine, Oregon Health & Science University, Portland, OR, USA.
Abstract:
This article reviews the performance, limitations, and implementation challenges of stool-based colorectal cancer (CRC) screening. Stool-based tests are becoming more essential in CRC screening due to their accessibility, affordability, and noninvasive nature. While screening performance varies among modalities, adherence to testing and timely follow-up remains the main barrier to effectiveness. Fecal immunochemical test (FIT) offers a favorable balance of sensitivity, cost, and patient uptake. Newer DNA-based and RNA-based tests improve early-stage cancer detection but are costlier and marginally less specific. Optimizing adherence while balancing diagnostic yield, cost, and environmental impact is essential to advancing stool-based CRC screening.
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