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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
SMARCA4-Deficient Undifferentiated Tumor of the Right Colon in a Patient With Ulcerative Colitis
Elizabeth Reynolds1, Fergus Reid2, Rawan ElManfalouty3
1Department of Surgery, East Lancashire Hospitals NHS Trust, Blackburn, GBR.
Abstract:
Undifferentiated gastrointestinal tumors with SMARCA4 deficiency are a rare subset of malignancies that often present as advanced, rapidly progressive disease. SMARCA4 loss is identified by immunohistochemistry, and affected tumors demonstrate distinct morphological features. Ulcerative colitis is a chronic inflammatory disorder that predisposes patients to colitis-associated colorectal cancer through a variety of genetic alterations. We present the case of a 31-year-old patient with a SMARCA4-deficient undifferentiated right-sided colon cancer detected during surveillance colonoscopy for ulcerative colitis. We also review the potential association between ulcerative colitis and SMARCA4-deficient undifferentiated gastrointestinal tumors.
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