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Updated: Sep 9, 2026

3' End Sequencing Library Preparation with A-seq2
Published on: October 10, 2017
QPL-enabled HTSlib library: accelerating sequence file compression using Intel IAA
Benjamin Laflen1, Zheyu Li1, Maxwell Urbina1
1Department of Computer Science & Engineering, UC San Diego, La Jolla, CA 92093, United States.
Summary:
Sequence analysis workflows require the accessibility of large datasets, which require state-of-the-art compression tools. These compression tools, such as Samtools, often rely on HTSlib as a GZip implementation, but are still limited by throughput on time-intensive compression. QPL-HTSLib offers order of magnitude speedups for the compression and decompression of the SAM and BAM file formats commonly used in genomics workflows at the cost of a slightly larger compressed file, and is a drop-in replacement for HTSlib on Intel systems.
Availability And Implementation:
QPL-HTSLib is freely available on Github as an open-source software project.
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