Related Experiment Video
Updated: Sep 12, 2026
09:27
The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
Published on: June 17, 2016
Dimethyl Fumarate-Associated Acute Hepatocellular Injury Assessed for Causality Using the Updated RUCAM: A
Ophir Lavon1,2, Maram Salameh3
1Rappaport Faculty of Medicine Technion-Israel Institute of Technology Haifa Israel.
Clinical Case Reports
|September 11, 2026
Abstract:
Dimethyl fumarate may rarely cause severe hepatocellular injury. In a 26-year-old woman, liver enzymes rose soon after treatment initiation, and biopsy supported DILI. Updated RUCAM assessment yielded 6, indicating probable causality, supported by dechallenge. Negative ANA reduced autoimmune hepatitis likelihood, although untested hepatitis E limited alternative-cause assessment and causal certainty.