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Updated: Sep 13, 2026
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Accessing P-Chiral Diphosphines through Nickel-Catalyzed Asymmetric Hydrophosphination
Chun-Yi Xiong1, Meng-Xiang Li1, Wei-Han Wang2
1State Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei230026, P. R. China.
Abstract:
Herein, we report a nickel-catalyzed asymmetric hydrophosphination of phosphine-borane-derived alkynes. This method delivers a series of structurally novel P-stereogenic bisphosphine derivatives. A broad range of alkynes and secondary phosphines was tolerated. The resulting bisphosphine products can be readily converted to P-chiral bisphosphine ligands by in situ deprotection. Using this strategy, we synthesized a series of chiral transition metal complexes that hold great promise for homogeneous catalysis.
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