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Changes in rat aortic actomyosin content with maturation.

C L Seidel, R A Murphy

    Blood Vessels
    |January 1, 1979
    PubMed
    Summary
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    Aorta

    Area of Science:

    • Cardiovascular Physiology
    • Biochemistry
    • Aging Research

    Background:

    • Aorta's maximum active force generating ability changes with age.
    • This study investigates the underlying molecular mechanisms of these age-related changes.

    Purpose of the Study:

    • To determine if actomyosin content changes in the aorta during maturation.
    • To correlate actomyosin content with force generating ability across different ages.

    Main Methods:

    • Quantitative gel electrophoresis to measure actin and myosin heavy chains.
    • Analysis of rat thoracic aorta from animals aged 3 to 43 weeks.
    • Normalization of actomyosin content by tissue mass, protein, and DNA.

    Main Results:

    Related Experiment Videos

  • Actomyosin content per tissue mass, protein, and DNA increased rapidly in the first 5 weeks.
  • Actomyosin content remained constant after 5 weeks of age.
  • No significant loss of contractile material was observed in later life.

    • Conclusions:

    • Increased actomyosin content early in life likely contributes to enhanced aortic force generation.
    • Age-related decline in aortic force generating ability later in life is not due to a loss of actomyosin.