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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
Published on: March 13, 2018
Plaque Reduction Neutralization Test Against Chikungunya Virus Using Liver Homogenate
Thais Alkifeles Costa1, Betânia Paiva Drumond2
1Laboratório de Vírus, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Abstract:
We adapted the plaque reduction neutralization test (PRNT) to detect chikungunya virus (CHIKV) neutralizing antibodies in liver homogenates instead of serum. This approach enables serological investigation using tissues collected from animal carcasses as nonhuman primate ones, during arbovirus surveillance, expanding opportunities for CHIKV monitoring and strengthening epidemiological surveillance efforts.
