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Updated: Sep 16, 2026

Isolation of Ribosome Bound Nascent Polypeptides in vitro to Identify Translational Pause Sites Along mRNA
Published on: July 6, 2012
SNOR: a path for ribosome recovery after hibernation
Brenna A Saladin1, Jailson Brito Querido1
1Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA; Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, USA.
Abstract:
Cellular dormancy requires ribosomes to be reversibly silenced yet preserved. Gluc et al. identify Shwachman-Bodian-Diamond syndrome domain-containing hibernation factor (SNOR), a fission yeast hibernation factor induced specifically by perturbed glucose homeostasis. Rather than driving translational shutdown, SNOR maintains dormant ribosomes in a state competent for rapid reactivation.
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