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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights
Wen Xiao1, Dan Tan1, Wen Zeng2
1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Abstract:
Metabolic reprogramming is an important factor contributing to tumor medication resistance and recurrence in cancer cells. There is ample proof that metabolic remodeling is vital in colorectal cancer's genesis, progression, and resistance to treatment. The molecular processes behind changes in metabolism in colorectal cancer are methodically examined in this review, including its interactions with the tumor microenvironment and key signaling pathways, and its potential clinical translational value. Investigating the metabolic characteristics of colorectal cancer and identifying novel metabolic biomarkers will provide essential support for early diagnosis and personalized therapy.
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